Labels:text | screenshot | black | font | black and white OCR: determine At present there is no reliable method t growth which patient has constitutional delay ir otrophin and which has total and complete gonad on have deficiency until several years of observa ted passed. In general, if puberty has not star rs, the spontaneously by the age of eighteen yea though patient probably has GnRH deficiency, al tient who there is at least one published case of a p five years spontaneously entered puberty at twenty of age. See later: . Isolated Gonadotrophin Deficiency · Multiple Hormonal Deficiency cy Tumours and Gonadotrophin Deficier aphin . Infiltrative Diseases Causing Gonadotr Deficiency iency · Radiotherapy and Gonadotrophin Def rophin · Congenital Disorders Causing Gonado Deficiency · Miscellaneous Disorders in Puberty